Two experimental studies were conducted in a laboratory setting, used to manipulate one-to-one SMC interaction. Experiment 1: Dependent on the experimental condition, in the experimental phase participants received manipulated replies, either with an empathic accurate or an empathic inaccurate message (i.e., positive vs. negative valence), with or without emojis (i.e., high vs. low richness of modality), and immediate replies or 7 minutes delay replies (i.e., synchronicity vs. asynchronicity). In the post-experimental phase social presence, both subjective and perceptive, attribution of other's personality, interpersonal trust and social support were assessed. Experiment 2 replicates the design of the Exp1 adding physiological measures. Two additional studies originated from this research project, analyzing smartphone-mediated communication with self-reported data (neuroticism, social anxiety, impulsivity, urge for gratification, dispositional trust, personality, smartphone use and smartphone addiction) have been conducted. Measures, pre-test details, methods and protocols are attached with datasets.